Undifferentiated nasopharyngeal cancer (UCNT): Current diagnostic and therapeutic aspects
Identifieur interne : 001096 ( Main/Exploration ); précédent : 001095; suivant : 001097Undifferentiated nasopharyngeal cancer (UCNT): Current diagnostic and therapeutic aspects
Auteurs : M. Altun [Turquie] ; A. Fandi [France] ; O. Dupuis [France] ; E. Cvitkovic [France] ; Z. Krajina [Croatie] ; F. Eschwege [France]Source :
- International Journal of Radiation Oncology, Biology, Physics [ 0360-3016 ] ; 1995.
Abstract
Undifferentiated carcinoma of the nasopharynx (UCNT) is a particular head and neck epidermoid lineage tumor related to the Epstein Barr Virus (EBV). It has geographically selective endemic epidemiologic features, without relation to external carcinogens. Its systemic agressiveness is the source of most disease-related demises, because radiotherapy achieves excellent local control and a significant percentage of cure in patients with exclusive locoregional disease. Differences in the staging systems currently in use, the recent changes in imaging and radiotherapy technology, and the lack of distinction between UCNT and squamous cell carcinoma (SCC) of the nasopharynx in Western literature reports make for some difficulty in therapeutic results evaluation when analyzing available literature. Its chemosensitivity is a relatively recent acknowledged fact, and its use in metastatic patients results in a high percentage of objective responses, many of long duration. Neoadjuvant cisplatin-based chemotherapy seems to be of benefit, but outstanding controversies in this regard will be soon answered through ongoing phase III trials. After a review of the current literature of all the above-mentioned aspects of this fascinating nosologic entity, our own experience, both in metastatic and locoregional disease patients is analyzed.
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DOI: 10.1016/0360-3016(95)00516-2
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It has geographically selective endemic epidemiologic features, without relation to external carcinogens. Its systemic agressiveness is the source of most disease-related demises, because radiotherapy achieves excellent local control and a significant percentage of cure in patients with exclusive locoregional disease. Differences in the staging systems currently in use, the recent changes in imaging and radiotherapy technology, and the lack of distinction between UCNT and squamous cell carcinoma (SCC) of the nasopharynx in Western literature reports make for some difficulty in therapeutic results evaluation when analyzing available literature. Its chemosensitivity is a relatively recent acknowledged fact, and its use in metastatic patients results in a high percentage of objective responses, many of long duration. Neoadjuvant cisplatin-based chemotherapy seems to be of benefit, but outstanding controversies in this regard will be soon answered through ongoing phase III trials. After a review of the current literature of all the above-mentioned aspects of this fascinating nosologic entity, our own experience, both in metastatic and locoregional disease patients is analyzed.</div></front></TEI><affiliations><list><country><li>Croatie</li><li>France</li><li>Turquie</li></country><region><li>Île-de-France</li></region><settlement><li>Savigny le Temple</li><li>Villejuif</li></settlement></list><tree><country name="Turquie"><noRegion><name sortKey="Altun, M" sort="Altun, M" uniqKey="Altun M" first="M." last="Altun">M. Altun</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Fandi, A" sort="Fandi, A" uniqKey="Fandi A" first="A." last="Fandi">A. Fandi</name></region><name sortKey="Cvitkovic, E" sort="Cvitkovic, E" uniqKey="Cvitkovic E" first="E." last="Cvitkovic">E. Cvitkovic</name><name sortKey="Cvitkovic, E" sort="Cvitkovic, E" uniqKey="Cvitkovic E" first="E." last="Cvitkovic">E. Cvitkovic</name><name sortKey="Dupuis, O" sort="Dupuis, O" uniqKey="Dupuis O" first="O." last="Dupuis">O. Dupuis</name><name sortKey="Eschwege, F" sort="Eschwege, F" uniqKey="Eschwege F" first="F." last="Eschwege">F. Eschwege</name></country><country name="Croatie"><noRegion><name sortKey="Krajina, Z" sort="Krajina, Z" uniqKey="Krajina Z" first="Z." last="Krajina">Z. Krajina</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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